Carpal Tunnel Syndrome, Menopause, and PMS Support
... The Significance of Daily Intake
In addition, some studies show that B6 may support the break-down of atherosclerotic plaque. Also, other studies show that B6 is a significant helper with menopause and premenstrual syndrome (PMS) issues -- especially when combined with magnesium and potassium.
Name: Vitamin B6, Pyridoxine
by Life Extension
Supplement Facts: Serving Size - 1 Vege Capsule
|Amount/Serving||% Daily Value|
|Vitamin B-6 (pyridoxine)||250 mg||12,500|
Other Ingredients: Vegetable cellulose (capsules), microcrystalline cellulose, vegetable stearate.
Does Not Contain: Yeast, dairy, egg, gluten, corn, soy, wheat, sugar, starch, salt preservatives, artificial color, flavor and fragrance.
Vitamin B6 -- Neurotransmitters, Liver Spots, Childrens' Growth, Menopause
Vitamin B6 is essential for amino acid absorption, metabolism and transport, the formation and growth of red blood cells, and for the utilization of many substances used by the nervous system. A deficiency of vitamin B6 may be associated with side effects associated with menopause, irritability, weakness and nervousness.
Vitamin B6 (pyridoxine) is an important component of the coenzyme PLP which metabolizes amino
acids. Because of its amino acid transfer ability, the body can produce nonessential amino acids from available amino
groups as well as metabolize protein and urea. It is essential because of its participation in more than 100 enzymatic
reactions including protein metabolism, conversion of
niacin, and neurotransmitter
As a natural anti-inflammatory support supplement, consuming bromelain (comes from pineapple) at 1,500 mgs/day, is recommended in conjunction with B6 at 500 mg in divided doses.
Vitamin B6 Deficiency Associated With Inflammation
In a study described online on May 23, 2012 in the Journal of Nutrition, researchers at Tufts University in Boston report a relationship between low levels of plasma pyridoxal-5'-phosphate (PLP), which indicate reduced levels of vitamin B6, with an increase in markers of inflammation."Low vitamin B6 status, based on plasma concentrations of pyridoxal-5-phosphate, has been identified in inflammatory diseases, including cardiovascular disease, rheumatoid arthritis, inflammatory bowel disease, and diabetes," writes Lydia Sakakeeny of Tufts Jean Mayer USDA Human Nutrition Research Center and her colleagues. "Our objective was to examine the association between plasma PLP and multiple markers of inflammation in a community-based cohort."
The current study included 2229 men and women enrolled in the Framingham Offspring study, who were recruited in 1971 and have undergone periodic examinations thereafter. Blood drawn between 1998 and 2001 was analyzed for plasma PLP and 13 markers of inflammation, including C-reactive protein, fibrinogen, interluekin-6, tumor necrosis factor-alpha and other factors.The researchers created inflammation scores based on the values of each inflammatory marker. An inverse relationship was observed between high inflammation scores and low levels of PLP. The authors note that decreased plasma PLP levels may reflect mobilization of PLP into inflammatory sites and that a causative relationship between reduced vitamin B6 levels and inflammation cannot be determined. However, they conclude that "This study in combination with past findings further supports our hypothesis that inflammation is associated with a functional deficiency of vitamin B6."
Caution: Some people have reported side effects symptoms of peripheral neuropathy (tingling, numbness sensation, decreased sensation to touch or balance difficulties) when taking vitamin B6 in doses above 500 mg daily -- especially if the nutrient is taken without other B-complex vitamins. Vitamin B6 may be toxic in doses of 2,000 mgs or more per day. Researchers (see Schaumberg below) have reported reversible nerve damage in four of seven patients who had been taking these amounts for two to four months. Five of the seven were women of which two were advised by their gynecologists to take the excessive amounts. One of the two men was taking these amounts as advised by his psychiatrist.
Recommended Dosage: One to two capsules per day (or, see above) in divided doses. It is recommended that vitamin B-6 (pyridoxine) be taken with other members of the B complex family. In addition, consider taking 1,500 mg of bromelain in divided doses.
Ellis, J.M. et al. "Response of Vitamin B6 deficiency and the carpal tunnel syndrome to pyridoxine." Proceedings of the National Academy of Science. 1982, 79:7494.
Ellis, J.M. "Free of Pain: Specific Types of Rheumatism." 1983. Southwest Publishing, Brownsville and Dallas, Texas.
Ellis, J.M. "Carpal tunnel syndrome and vitamin B6." Southern Medical Journal. 1987, 80:882.
Abraham, G.E., and Hargrove J. "Effect of vitamin B6 on premenstrual (PMS) symptomatology in women with premenstrual tension syndromes: A double-blind crossover study." Infertility. 1980, 3:155.
Kasden, M.L., and James, C.J. "Carpal tunnel syndrome and vitamin B6." Plastic and Reconstructive Surgery. 1987, 80:882.
Rinehart, J.F., and Greenberg, L.D. "Arteriosclerotic lesions in pyridoxine deficient monkeys." American Journal of Pathology. 1969, 25:481.
DiSorbo, D.M., and Nathanson, L. "High dose pyridoxal supplemented culture medium and the growth of a human malignant melanoma cell line." Nutrition and Cancer. 1983, 5(1):10.
DiSorbo, D.M., Wagner, R. Jr., and Nathanson, L. "In vivo and in vitro -- B16 melanoma growth and B6." Nutrition and Cancer. 1985, 7:43.
Baumblat, M.J., and Winston F. "Pyridoxine and the pill." Lancet. 1970, 1:832.
Adams, P.W. et al. "Influence of oral contraceptives, pyridoxine, and tryptophan on carbohydrate metabolism." Lancet. 1976, 1:759.
Schaumberg, H. et al. "Sensory neuropathy from pyridoxine abuse." New England Journal of Medicine. 1983, 309:445.
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