Tumeric (Turmeric/Circumin) - Alzheimer's Disease/Cognitive Therapy

Circumin, the pigment responsible for turmeric's yellow color, helps immune cells clear out the plaque build-up that is thought to play a role in Alzheimer's disease, a new study indicates.

Alzheimer's disease patients have defects in phagocytosis, the process immune cells use to gobble up amyloid-beta, plaque deposits in the brain that are associated with Alzheimer's. They also have defects in their bodys ability to clear amyloid-beta plaques. In animal experiments, circumin enhanced brain clearance of amyloid-beta. Consequently, in the current study, scientists treated immune cells (macrophages) from six Alzheimer's disease patients and three controls with circumin in vitro and measured amyloid-beta uptake.

At baseline, the intensity of amyloid-beta uptake by the macrophages from Alzheimer's patients was significantly lower in comparison to control macrophages. After treatment of macrophages with the circumin compound, amyloid-beta uptake by macrophages from three of the six Alzheimers patients was significantly increased.

The age of the patient and the stage of the Alzheimer's disease appeared to influence the effectiveness of tumeric/circumin. The most benefit occurred in the cells from younger patients and patients with early-stage Alzheimer's. The circumin appeared to have no effect on the macrophages from the healthy controls.

According to the researchers, Immunomodulation of the innate immune system by curcuminoids might be a safe approach to immune clearance of amyloidosis in [the] Alzheimers disease brain.

Reference
Zhang L, Fiala M, Cashman J, Sayre J, Espinosa A, Mahanian M, Zaghi J, Badmaev V, Graves MC, Bernard G, Rosenthal M. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. J Alzheimers Disease. 2006 Nov;10(1):1-7.

Curcumin & Cancer Support

Order: Tumeric (circumin) | Herbal Formula (contains curcumin)

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