TMG (trimethylglycine) 50gm - Betaine Hydrochloride

TMG (trimethylglycine) 50gm - Betaine Hydrochloride - Information
Reprinted by permission from Bill Faloon of The Life Extension Foundation

TMG (trimethylglycine)

TMG, or trimethylglycine, is a potent remethylation agent derived from sugar beets. This supplement is used to protect against the damaging effects of a toxic amino acid called homocysteine. Elevated homocysteine has also been linked to complications in many health conditions. The tri means there are three methyl groups on each glycine molecule that can be transferred to homocysteine to remethylate it into methionine and s-adenosyl-L-methionine (SAMe). This remethylation or detoxification of homocysteine requires the following co-factors: folic acid, vitamin B6, vitamin B12, zinc, and TMG.

TMG is also called glycine betaine, but the name trimethylglycine signifies that it has three methyl groups attached to each molecule of glycine. In the body, TMG donates one of its methyl groups to cellular DNA. Betaine was discovered to be beneficial to heart health back in the 1950s.

When a TMG methyl group is donated to a molecule of homocysteine, it is converted first to the nontoxic amino acid, methionine, then to S-adenosyl-methionine (SAMe).

Research showing TMG's ability to promote healthy levels of homocysteine alone or in conjunction with other nutrients, confirms its status as an important nutrient for cardiovascular health.

While TMG, folic acid, vitamin B6, and vitamin B12 help to lower homocysteine, it is impossible for any individual to know if he / she is taking the proper amount of nutrients without a blood test. The Life Extension Foundation offers a homocysteine blood test to ensure that ones supplemental regime brings homocysteine down to a safe range.

Startling New Findings About Homocysteine

Original research conducted by Life Extension years ago, however, showed that there is a huge individual variability in the amount of B vitamins needed to keep homocysteine in optimal (safe) ranges. Life Extension found that a substantial percentage of members who were taking the recommended potencies of B vitamins were not achieving adequate homocysteine control. In these members with elevated homocysteine, higher doses of vitamin B6 and/or TMG (trimethylglycine) were needed to bring homocysteine down to the safe range.

Doctors who fail to check their patients blood for homocysteine regularly and adjust the B vitamin dose accordingly are not going to reduce homocysteine to safe ranges in most of their patients. It is usually up to the patients themselves to take the initiative to inform their doctors that they intend to maintain their blood homocysteine levels below 7-8 mmol/L of blood.

What Causes Homocysteine Overload
Some people have high blood homocysteine early in life, while others dont manifest dangerous levels until they grow older. According to every scientific study we could find, most aging people accumulate too much homocysteine in their blood. One reason for this is that the methylation detoxification system that normally disposes of homocysteine becomes defective with aging. Healthy methylation reactions convert homocysteine back into its amino acid precursor, methionine. Supplements that facilitate healthy methylation reactions in the body include folic acid, vitamin B12, and TMG.

Another way the body rids itself of excess homocysteine is through the trans-sulfuration pathway, which is dependent on vitamin B6. As long as adequate levels of vitamin B6 are present, homocysteine is converted into beneficial cysteine in the body via this trans-sulfuration pathway.

Those with moderate homocysteine elevation may respond to the daily intake of 800 mcg of folic acid, 600 mcg of vitamin B12, 100 mg of vitamin B6, and 500 mg of TMG. Life Extension has found that aging members sometimes require vitamin B6 in doses ranging from 250 to 1000 mg a day and/or 1500 to 3000 mg of TMG a day to reduce homocysteine to a safe range (below 7-8 mmol/L of blood). Reducing consumption of foods that contain lots of methionine (such as red meat and chicken) can lower homocysteine.

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