Sam-e (S-Adenosylmethionine) Amino Acid, Vitamins, Supplements

Sam-e (S-Adenosylmethionine) Amino Acid, Vitamins, Supplements

Jarrow Formulas' S-Adenosyl Methionine (SAM-e) 200 and 400 is foil blister-packed to maximize stability and safety. Do not use if outer seal of blister pack is broken. Full Potency 200mg elemental SAM-e is derived from 400mg of tosylate disulfate SAM-e.

Jarrow Formulas' SAM-e 200 and 400 pharmaceutical grade, stabilized SAM-e, is a full 200mg elemental SAM-e from 400mg of SAM-e tosylate disulfate. SAM-e 200 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

SAM-e is a chiral molecule and therefore consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas' SAM-e is made naturally by microbiological fermentation and then specially processed to preserve 68-80% (S,S) SAM-e, the highest active level available.

SAM-e (S-Adenosylmethionine) is an amino acid derivative that has been clinically proven. Found in all living cells, SAM-e is also called activated methionine (an essential amino acid) since it is formed by the combining of ATP with methionine. SAM-e has undergone dozens of trials. Researchers studying the beneficial effects of SAM-e have identified the following benefits of SAM-e:

Joints
SAM-e supports healthy connective tissue through transulfuration. In this process, critical components of connective tissue, including glucosamine and the chondroitin sulfates, are sulfated by SAM-e metabolites.

Brain
SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-dopa, dopamine and related hormones, epinephrine and phosphatidylcholine (a component of lecithin).

Liver
SAM-e supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase).

Longevity
Methylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process. Proper methylation through substances such as SAM-e positively influences longevity.

Dosage
The label on the Jarrow product you receive states "Take 1 to 3 tablets per day before meals, or as directed by your qualified health consultant." Most eating experts suggest consuming 5-6 meals per day so this statement may be misleading. A more accurate dose model would be:

The effective oral dose of SAMe is 800-1600 mg/day. The Life Extension Foundation recommends people begin by taking four 200 mg tablets per day-once in the morning, and once in the afternoon. Another tablet or two should be added at noon, conditions do not improve within 2 days. Another tablet in the evening may be necessary for some people. Some people have been given 1600 mg from the first day without significant adverse effects beyond dry mouth and nausea.

Jarrow Formulas’ SAMe 200 contains pharmaceutical grade stabilized S-AdenosylMethionine (SAM-e), a naturally occuring compound produced by the body. SAMe is formed when the body combines the amino acid L-methionine with ATP (adenosine triphosphate), the primary energy molecule found in physiologic processes. SAMe may be the most active and efficient of the various methyl donors currently known. SAMe is considered "The Active Methionine." It is utilized for transmethylation, transulfuration and amino propylation.

Jarrow Formulas' SAM-e 200 is foil blister-packed to maximize stability and safety. Do not use if outer seal of blister pack is broken. Full Potency 200mg elemental SAM-e is derived from 400mg of tosylate disulfate SAM-e.

Jarrow Formulas' pharmaceutical grade, stabilized SAM-e 400 is a full 400 mg elemental SAM-e from 800 mg of SAM-e tosylate disulfate. SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

SAM-e 200 and 400 is foil blister-packed to maximize stability and safety. Do not use if seal of blister pack is broken.

Store in a cool, dry place. Suitable for vegetarians.

Warnings Information:

For dietary supplement use only
Keep Sam-e (S-Adenosylmethionine) vitamins, supplements by Jarrow out of reach of children
Do not exceed recommended dosage
If you have a bad reaction, discontinue use immediately
When using, please inform your physician
If you are pregnant, lactating or have a medical condition, consult your health care professional before using this or any other nutritional supplement.
If the effects of allergic reaction occurs, discontinue immediately.
Individuals using prescribed medications such as antidepressants, including Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using.
Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use Sam-e (S-Adenosylmethionine) vitamins, supplements by Jarrow.

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