Saffron A, Loose Weight Loss, Crocus Sativus, Buy, Side Effects, Appetite Suppressant/Dose
As seen on the Dr. Oz Show

Serotonin's Role in Emotional Eating
Although its precise neurochemical mechanisms of action were confirmed only this year, the fundamentally psychiatric nature of what some experts call emotional eating has received clinical validation in an abundance of studies.9-12  When severe enough, it reaches the level of a compulsion -- a clinically diagnosable anxiety-related disorder.  Compulsive eating occurs in about 30% of obese women,13 although its prevalence in the general population greatly exceeds that number.  It is strongly correlated with poor impulse control, depression,14 and relapse following weight loss.15  In keeping with anecdotal observation, research shows its victims tend to gravitate toward sweet, non-nutritious foods16 like candy and ice cream making it difficult to loose weight.

In one of the most compelling findings on emotional eating to date, Dutch researchers reported that compulsive eating can result from a common gene variant for the molecule that transports serotonin, one of the body's primary mood regulators.17  People carrying this gene suffer from lower serotonin activity, predisposing them to depression and anxiety, especially under stress.18-20  The Dutch study revealed that teens carrying this gene indulge in emotional eating at a significantly higher rate.

Antidepressants may offer some relief from emotional eating.  Unfortunately, they can be costly, loose effectiveness over time, and come with a host of side effects from sexual dysfunction to suicidal thoughts21-23 underscoring the need for safe, low-cost options.

Saffron Extract:  A Novel Intervention
Thanks to a team of pioneering French scientists, a next-generation natural alternative has come to light.  Saffron has been used in traditional Persian medicine for centuries as a treatment for insomnia and anxiety.24  French researchers Cedric Bourges and his colleagues Jacques Noury and Bernard Gout25,26 set out to corroborate these therapeutic positive side effects and apply them to the treatment of eating disorders.  They hypothesized that through an action against the anxiety component of eating behaviors such as food compulsions, saffron could alleviate the need for food between meals.26

They first conducted a pilot placebo-controlled study using a proprietary saffron extract in a small group of healthy-to-slightly overweight women aged 46-61.25  Their results were modest:  3.6 pounds lost, almost all of it fat weight, after 4 weeks.

More striking to Bourges and his team were the significant declines in reported feelings of hunger between meals, a positive side effect that persisted until dinner in 25% of women taking the saffron extract.25  In contrast, 50% of placebo recipients reported an increased desire to eat.  By the end of the study, 100% of women in the saffron group reported successful reduction in daily between-meal eating, as opposed to controls, who saw no improvement.

Armed with these encouraging findings, Bourges and his colleagues launched a full-scale trial of 60 slightly overweight women 25-45 years old.26   This time, they focused specifically on women who reported frequent, anxiety-related between-meal and after-dinner snacking.  Their goal was to test the saffron's psychotropic (mood-altering) potential in helping to reduce the anxiety behind compulsive eating.

Once again, weight loss was relatively modest ... over one pound at the 2-week mark versus a slight gain in the placebo group.  By 8 weeks, the average weight loss had increased, reaching just over two pounds, with 26% of subjects losing up to 11 pounds.  Interestingly, women taking saffron saw a significant reduction in thigh circumference.

It was the positive psychological side effect reported in the saffron group that again proved most compelling, especially given this cohorts susceptibility to compulsive between-meal consumption.  The women reported a significant reduction in feelings of hunger before meals.  They also experienced a significantly diminished need to snack between meals.  The favorable alteration in these urges had concrete results.  At baseline, women in both groups had reported an average of about 12 snacking episodes per week.  After eight weeks, the average was just six episodes per week in the saffron group -- a 50% reduction. These results validated the French teams hypothesis:  Something about this particular saffron extract was working to control the compulsion to eat in this vulnerable sample of women who wanted to loose weight.  They reported that subjects in the saffron group felt significantly more alert and energetic than the placebo group26 -- feelings that correspond with emergence from sub-clinical depression and anxiety.  As noted above, depression and anxiety are the foundation for compulsive eating.  The key to this saffron extracts potency, it turned out, lay in its effects on levels of serotonin.

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