Quercetin (Quercitin) - Resveratrol Antioxidant, Allergies and Cancer Support, Side-Effects

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Quercetin
Enhanced Antioxidant Protection -- Heart Disease, Cancer, Allergies, and More - Page 2
By Julius Goepp, MD


Korean researchers in 2007 showed how quercetin inhibits the production of inflammatory cytokines by blocking the side effects of the powerful cellular mediator NF-kappaB, long associated with both cancer and chronic inflammatory conditions.8

Quercetins anti-inflammatory effects may arise in part from its inhibitory effects on the inflammation-producing enzymes cyclooxygenase (COX) and lipo-oxygenase (LOX).  This in turn leads to a decrease in inflammatory mediators such as prostaglandins and leukotrienes.2,9  Pharmaceutical agents that block the COX enzymes are often used in the management of painful conditions like arthritis, while LOX inhibitors are employed in the management of asthma.

Additionally, quercetin exerts protection against allergies and inflammation by helping prevent the release of histamine from mast cells and basophils, thus acting as a natural antihistamine side effects free.2  This is similar to the mechanism of action of the drug cromolyn which is used to manage allergy-related asthma.

Researchers in both Brazil10 and Korea11 protected animals from fatal allergic reactions to common food allergens by pre-treating them with quercetin in oral or inhaled forms.

Quercetins ability to prevent allergic effects has tremendous implications for the treatment and prevention of asthma and bronchitis, conditions for which quercetin-rich foods have had long traditional roles.12  Several studies since 2007 have shown that animals pre-treated with quercetin or related compounds have dramatically reduced side effects to chemicals that trigger asthma attacks.13-15

In a dramatic study in 2008, Korean researcher Hee Moon compared inhaled quercetin head-to-head with prescription asthma drugs in guinea-pigs.16  Remarkably, the nutrient-derived quercetin treatment reduced airway resistance (difficult breathing) more than the adrenaline-like drug albuterol and had equivalent effects to the anti-inflammatory cromolyn as well as the potent steroid dexamethasone.

In a form of epidemiological detective work, nutrition scientists from Michigan State University explored the impact of dietary flavonoids such as quercitin in their more general roles as systemic anti-inflammatory agents.  Basing their work on knowledge that intake of certain foods can lower levels of the inflammatory risk factor C-reactive protein (CRP), they went looking for the most potent food components, studying more than 8,000 adults.  They found that higher flavonoid intake was associated with lower CRP levels and quercetin headed the list of specific flavonoid compounds that had the strongest protective effect.  Since elevated CRP levels are associated with numerous disease states such as obesity, heart disease, and lupus, this provides compelling reason to explore its potential for preventing death and disability from a host of major killers.

Immune-Modulating Effects
Quercetin is one of nearly 200 beneficial compounds found in garlic18 which has been used for millennia in treating and preventing infectious disease such as viral syndromes.19  Indeed, modern science confirms its benefits in helping fight off viral invaders and their side effects.

In laboratory studies, quercetin has been found to reduce the replication and infectivity of numerous viruses, including respiratory syncytial virus (a common cause of childrens upper respiratory infection) and para-influenza virus type 3.2

Italian researchers just last year showed that they could use a quercetin-rich extract to up-regulate the antiviral immune response in cells infected with herpes viruses.20  Additionally, an animal study last year showed that supplementation with quercetin helped protect mice against influenza infection following exercise-induced stress.21  These findings make quercetin an intriguing candidate for preventing and managing viral infections in susceptible individuals.

Obesity
The rampant rise of obesity poses one of the greatest global health threats today.  Scientists are now eagerly exploring quercetins potential as a means of controlling fat accumulation.
Quercetin in Wine - Obesity Support

Fat, long considered to be an inert and biologically uninteresting tissue, is now known to be a virtual beehive of metabolic and endocrine activity.  It helps produce a myriad hormones, inflammatory cytokines, and other molecules that influence health for better or for worse.22  Fat tissue mass is essentially the product of new fat cells, their accumulation of fat triglycerides (blood fats), and their programmed death (apoptosis).23  Each of these processes can be affected by various natural dietary components.  As University of Georgia nutritionist Srujana Rayalam recently observed, Therapy employing compounds that target different stages of the adipocyte [fat cell] life cycle might prove beneficial for decreasing adipose tissue volume by inducing apoptosis or by inhibiting adipogenesis [fat accumulation] or both.23  What is so exciting about quercetin is recent evidence that this flavonoid, alone or in combination with resveratrol and genistein, is capable of exerting just such multiple effects directly on fat tissue.

Quercetin inhibits fat accumulation in maturing human fat cells in culture, for example, while also suppressing the maturation of new fat cells and simultaneously triggering apoptosis (programmed cell destruction) in existing fat cells.24,25  Quercetin actually blocks the uptake of glucose from the blood, depriving fat cells of the raw material they need to manufacture and accumulate fat molecules.26  In remarkable work published in 2008, the University of Georgia group found that while they could block fat cell production and enhance fat cell death dramatically using either quercetin or resveratrol (another powerful flavonoid) alone.  When they used the two in combination they decreased lipid (fat) accumulation in cultured fat cells by nearly 70% while increasing fat apoptosis by a whopping 310%. 27

Just a few months later, the same research team found that resveratrol and genistein synergize with quercetin to decrease lipid accumulation in human fat cells.  While genistein, quercetin, and resveratrol decreased lipid accumulation in fat cells by 17%, 20%, and 17%, respectively, the combination of all three agents decreased lipid accumulation by an impressive 80%.25

Studies in animals lend support to the potential anti-obesity effects of quercetin.  In mice fed a high-fat diet, quercetin produced a transient increase in energy expenditure,28 while another study showed that high-dose quercitin supplementation was associated with reduced body weight gain in obese, insulin-resistant mice.3

Its no surprise that quercetin, alone or in combination with other nutraceuticals, is drawing the attention of researchers searching for novel strategies for fighting obesity via numerous mechanisms.

What You Need to Know: Quercetin

  • Despite being the most common and best studied of the polyphenols, quercetin has been largely neglected in the public eye until recently.  New research has revealed its astonishing potential as a health-promoting, disease-preventing supplement.
  • The powerful antioxidant effects directly reduce tissue damage and have now been shown to possibly have a positive effect on diseases such as cancer and heart disease.
  • Independent effects of quercetin directly reduce fat tissue growth and development and even reduce the bulk of body fat stores promoting health through weight reduction.
  • Quercetin shows promise in fighting the numerous components of the metabolic syndrome including hypertension, insulin resistance, and adverse lipid profiles.
  • Its antioxidant effects may lead to anti-inflammatory and anti-allergy effects.
  • Quercetin directly extends the life span of laboratory organisms, in part by mimicking the beneficial side effects of caloric restriction and opening the door to a new approach to life extension itself.
  • Health care practitioners recommend quercetin in doses ranging from 50 mg to 500 mg, one to three times daily.2,55

Cardiovascular Disease
Increased dietary intake of flavonoids, particularly from quercetin-rich foods, has been linked with decreased heart disease mortality and decreased stroke incidence.2  In 2000, Spanish scientists showed that red wine, laden with quercetin and related antioxidants, prevented activity of inflammation-promoting NF-kappaB in human volunteers, providing a big part of the explanation of how red wine reduces cardiovascular mortality.29

In 2004, British researchers demonstrated that humans who took quercetin supplements had substantially reduced platelet aggregation, suggesting that another of its cardiovascular health benefits was related to a reduced risk of clotting.30  These researchers later showed that dietary ingestion of quercetin from onion soup also helped inhibit platelet aggregation.31  And, in a study of 30 men who already had coronary heart disease, Greek cardiologists showed that a red grape polyphenol extract rich in quercetin caused an increase in flow-mediated dilation of major arteries, a potent indicator of improved endothelial health.32

The natural next step was to study quercetin supplements alone and their effect on blood pressure -- a study undertaken at the University of Utah in 2007.33  They studied 19 patients with pre-hypertension and 22 with stage 1 (early) hypertension, supplementing them with placebo or 730 mg quercetin/day for 28 days.  There was no effect on the pre-hypertensive patients but the hypertensive group enjoyed reductions in both systolic and diastolic blood pressure (average 7 mmHg and 5 mmHg reductions, respectively) ... meaningful changes that lower vascular disease risk.

In 2008, a randomized, placebo-controlled crossover trial in 12 healthy men showed biochemical evidence of improved endothelial function (such as augmentation of nitric oxide status) with as little as 200 mg/day of quercetin.34

Together, these effects point to an important role for quercetin in protecting cardiovascular health.

Metabolic Syndrome and Diabetes
Chinese folk medicine has long used a quercetin-rich plant called Euonymus alatus to treat type 2 diabetes.35  Not surprisingly, modern research is finding that quercetin may hold applications in managing metabolic syndrome -- a cluster of risk factors that is associated with an elevated risk of diabetes.

Spanish researchers publishing in the journal Obesity showed in 2008 that quercetin given to obese, insulin-resistant rats produced a reduction in systolic blood pressure, plasma lipids, and insulin levels, while improving the over-aggressive inflammatory status these rats develop.3  The higher of two experimental quercetin doses also led to increased expression of endothelial nitric oxide synthase -- the enzyme that generates blood vessel-protective nitric oxide.  These findings suggest that quercetin may protect against numerous components of the common and deadly metabolic syndrome.

 Bronchitis / Asthma

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