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Quercetin
Clinical evidence of quercetin’s usefulness in cancer prevention and therapy is rapidly accumulating. An early Phase I clinical trial of quercetin in patients with various cancer types demonstrated a decrease in activity of enzymes required for tumor growth in 9 of 11 patients studied.48 Two patients with advanced cancers that failed to respond to standard chemotherapy experienced significant drops in chemical tumor markers during the study. More recently, Cleveland Clinic oncologists investigated quercetin in patients who had familial adenomatous polyposis, an inherited condition producing hundreds of colonic polyps that ultimately turn to cancer.49 They combined the quercetin with curcumin, another nutrient with known anti-inflammatory and tumor-blocking potential. Both nutrients were taken by five patients and they were followed for six months. All patients had a reduction in both size (60%) and number of polyps (51%) over the course of treatment with minimal adverse effects and no evidence of laboratory abnormalities. The researchers strongly encouraged larger controlled trials to further explore the supplements’ potential cancer-fighting abilities.
Biologists at Humboldt University in Berlin took these findings several steps further in their work on a simple roundworm, C. elegans. They demonstrated that feeding the tiny worms flavonoid-rich diets improved overall health and longevity.50 Digging deeper, the same group traced this powerful effect to the quercetin content of the supplement. They’ve even identified a set of four specific genes that seem to be activated by quercetin, pinpointing the precision with which this nutrient acts.50,51 Other scientists have found evidence that quercetin may mimic many beneficial biological effects of caloric restriction, which extends life span in animals and humans.5,52,53 The immediate impact on humans has also been shown by neuroscientists in Kentucky. They discovered that brain cells could be protected from the devastating effects of the toxic protein found in Alzheimer’s disease, beta-amyloid. They pre-treated the cells with quercetin and this apparently reduced free radical damage caused by the deadly protein.54 Dosage and Safety Summary Warnings Information:
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