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Progesterone Cream (ProFem) Low Levels, Side-effects - Dose
Supplement Facts -- 2 oz Cream
Pro Fem Natural Progesterone Cream - liposome delivery (measuring spoon included) - 2 oz jar (USP - United States Pharmacopia) conforms to the legal requirements of the U.S. Food and Drug Administration. Products or ingredients labeled USP also mean that they are produced in accordance with the principles outlined in the FDA’s Good Manufacturing Practices. 2.5% progesterone minimum.Ingredients: Purified water, glycerin, safflower oil, alkoxylated diester, cetyl alcohol, progesterone, sorbitan stearate, PEG-40 stearate, cyclomethicone, glyceryl stearate, benzyl alcohol, imidazolidinyl urea, methylparaben, carbomer, D-alpha tocopherol, propylparaben, sodium hydroxide, citrus seed extract, cholesterol, lecithin, disodium EDTA.
Dose and Use (women)
Massage ProFem Progesterone Cream into soft tissue areas such as chest, breast, underarms, face, abdomen, buttocks, or inner thighs and apply to a different area every day to avoid saturating the skin/fat cells.
For menopausal women, the following regimen is suggested:
~ First jar: use 1/2 teaspoon morning and night.
~ Second jar: use 1/4 teaspoon morning and night.
For premenopausal women, the following regimen is suggested:
~ Days 1 to 11 of cycle: no application.
~ Days 12 to end of cycle: 1/8 to 1/4 teaspoon daily.Dosage and Use (men)
1/8 teaspoon ProFem Progesterone Cream should be used once or twice daily by massaging into soft tissue areas.Progesterone: First Hormone to Decline
While traditional medicine focuses on diminished estrogen levels, progesterone is the first hormone that declines as the body ages. Some women in their late twenties have progesterone deficiencies, while other women in their late forties and even early fifties are still producing youthful levels of progesterone. This is why hormone testing and individually designed treatments are so essential.
Progesterone is primarily manufactured in the adrenal glands and ovaries, though some is produced in the brain. This hormone is necessary for gestation to occur, and miscarriages are common when progesterone is deficient. Symptoms of a deficiency include premenstrual discomfort, night sweats, hot flashes, and a loss of well being, often including negative moods. Supplementation with natural progesterone reduces the prevalence of these events.
John Lee, MD, originated the clinical use of bioidentical progesterone. Reports by Dr. Lee and others have suggested that natural progesterone stimulates new bone formation by increasing osteoblast activity. While vitamin and mineral deficiencies, poor eating habits, and lack of exercise also contribute joint problems, hormone imbalances -- especially estrogen and progesterone deficiencies -- play a significant role in the progression of bone problems in women.
Several studies have found that topical progesterone creams can be effective. A one-year trial in postmenopausal women saw a significant reduction in vasomotor symptoms such as hot flashes in a group using a bioidentical transdermal progesterone cream. Researchers also noted reduced thickening of the uterine lining produced by an estrogen drug when postmenopausal women used a transdermal or vaginal progesterone cream for four weeks. This antiproliferative effect is one of the main reasons that traditional doctors prescribe medroxyprogesterone, a progestin (progesterone-like drug) known as Provera® which produces numerous side effects. Synthetic progestin drugs do not function the same way as natural progesterone. Moreover, because progesterone enhances the sensitivity of estrogen receptors in cell membranes, the use of a natural progesterone cream may permit a reduction in estrogen supplementation.
Bioidentical progesterone has also been shown to reduce problems associated with the breast. Researchers at National Taiwan University Hospital found that progesterone reduces the proliferation rate of breast epithelial cells. Another study examined breast problems in women with progesterone deficiencies. The scientists discovered that hormone-deficient women were 5.4 times more likely to have premenopausal breast problems and 10 times more likely to die than were women without a progesterone deficiency.
An even more intriguing study revealed that survival rates for breast surgery are strongly correlated with the patient’s progesterone level on the day of surgery. Because it is involved in the menstrual cycle, progesterone concentrations vary dramatically at different times of the month. This study noted that 65% of women with a progesterone level of 4 nanograms (ng) per ml or more on the day of their surgery were alive 18 years later, while only 35% of women with low progesterone levels on that day were still living after 18 years. The researchers noted that progesterone lowers the expression of vascular endothelial growth factor, which promotes the increase in new blood vessels (angiogenesis). This strongly suggests that women should time their surgery to match their monthly peak in progesterone.
“The best results from progesterone supplementation are obtained when the natural monthly fluctuation in this hormone is followed as closely as possible,” notes Dr. Wright. “There should be a monthly pause in progesterone supplementation, because that’s what our bodies naturally do. Progesterone and estrogen are produced and received by their hormone receptors in cyclic fashion, with a brief lull every month. This ‘down time’ probably helps prevent long-term receptor down-regulation. As a general rule, I recommend using a progesterone cream from day 12 of the cycle until three to five days before the start of the next cycle. However, women with a family history of bone problems may need more days of progesterone exposure because this hormone positively influences bone formation."Caution: Consult your physician before using Pro Fem Progesterone Cream if you have progesterone or estrogen-dependent cancer. Keep out of reach of children.
Warnings Information:
- For dietary supplement use only
- Keep ProFem Progesterone Cream out of reach of children
- Do not exceed recommended dosage
- If you have a bad reaction, discontinue use immediately
- When using, please inform your physician
- If you are pregnant, lactating or have a medical condition, consult your health care professional before using this or any other nutritional supplement.
- If the effects of allergic reaction occurs, discontinue ProFem Progesterone Cream immediately.
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