Magnesium, Glucosamine, CoQ10, Melatonin -- Conclusion/References

Magnesium, Glucosamine, CoQ10, Melatonin, Feverfew, Butterbur - Conclusion/References

Other Intriguing Possibilities
While physicians continue to explore how magnesium, riboflavin, feverfew, and butterbur work, several other therapies also are under study.

Glucosamine - Doctors at Canadas Brampton Pain Clinic studied 10 people. All suffered and none had been helped by previous standard treatments.23 After they took glucosamine for 4-6 weeks, the volunteers reported a drop in the number and intensity of pain. The researchers theorize that glucosamine works through white blood cells called mast cells to boost the production of heparin, which helps to reduce blood clotting, thus reducing nerve-mediated inflammation and pain. How much glucosamine is required to prevent migraines is unknown, but the therapeutic dose may be similar to that used to support joints (approximately 1,800 mg per day).

Coenzyme Q10 (CoQ10) - This vitamin-like substance may aid people by stimulating the mitochondria to produce more energy. A 2002 study published in the journal Cephalgia reported on 32 patients treated with a daily dose of 150 mg of Coenzyme Q10 (CoQ10) for four months.24

By the study's end, the average number of attacks per month fell from 4.85 to 2.81, and CoQ10 did not trigger any reported side effects. If the results of this preliminary study are confirmed by double-blind studies, 150 mg per day of CoQ10 may become the recommended dose.

Melatonin - Secreted by the pineal gland at night to aid in sleep, this hormone also may play a role in the genesis of head pain. French researchers noted abnormal melatonin levels in the blood of four of six women who suffer from head pain (compared to nine healthy people serving as controls).25 The scientists theorized that problems with the pineal gland may be responsible for pain in some people, thus explaining why melatonin may help.

Some 28 million Americans suffer from some form of head pain, which calculates to approximately one person in every four households. While standard medications are helpful, millions may find additional relief in natural, readily available substances such as magnesium, riboflavin, feverfew, butterbur, glucosamine, CoQ10, and melatonin.

References:

1. Educational Resources: NHF Fact Sheet page. National Foundation web site. Accessed November 25, 2003.

2. CoQ10s possible new target: Life Extension Magazine, April 2003:28.

3. Khosh F. Natural approach to head pain. Townsend Letter for Doctors and Patients, Aug-Sep 2002.

4. Mauskop A, Altura BM. Role of magnesium in the pathogenesis of pain. Clin Neurosci 1998;5(1):24-7.

5. Mauskop A, Altura BT, Cracco RQ, Altura BM. Serum ionized magnesium levels in patients with tension-type pain. Olesen J and Schoenen J, eds. Mechanisms, and Treatment. New York: Raven Press; 1993: 137-40.

6. Mauskop A, Altura BT, Cracco RQ, Altura BM. Deficiency in serum ionized magnesium but not total magnesium in patients . Possible role of ICa2+/IMg2+ ratio. Headach 1993 Mar;33(3):135-8.

7. Mauskop A, Altura BT, Cracco RQ, Altura BM. Intravenous magnesium sulphate relieves attacks in patients with low serium ionized magnesium levels: a pilot study. Clin Sci (Lond) 1995 Dec;89(6):633-6.

8. Mauskop A, Altura BT, Cracco RQ, Altura BM. Intravenous magnesium sulfate rapidly alleviates various types. Headace 1996(Mar);36(3):154-60.

9. Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalagia 1996 Jun;16(4):257-63.

10. Facchinetti F, Sances G, Borella P, Genazzani AR, Nappi G. Magnesium prophylaxis of menstrual issues: effects on intracellular magnesium. Heaache 1991 May;31(5):298- 301.

11. Durlach J, Durlach V, Bac P, Bara M, Guiet- Bara A. Magnesium and therapeutics. Magnes Res 1994 Dec;7(3-4):313-28.

12. Schoenen J, Lenaerts M, Bastings E. High- dose riboflavin as a prophylactic treatment: results of an open pilot study. Cephalgia 1994 Oct;14(5):328-9.

13. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in prophylaxis. A randomized con trolled trial. Neurology 1998 Feb;50(2):466- 70.

14. Southon S, Bailey Al, Wright AJ, Belsten J, Finglas PM. Mircronutrient undernutrition in British schoolchildren. Proc Nutr Soc 1993 Feb;52(1):155-63.

15. Johnson ES, Kadam NP, Hylands DM, Hylands PJ. Efficacy of feverfew. Br Med J (Clin Res Ed) 1985 Aug 31;291(6495):569-73.

16. Murphy JJ, Heptinstall S, Nitchell JR. Randomized double-blind placebo controlled trial of feverfew in prevention. Lancet 1988 Jul 23;2(8604):189-92.

17. Prusinski A, Durko A, Niczyporuk-Turek A. Feverfew as treatment. Neurol Neurochir Pol 1999;33 Suppl 5:89-95.

18. Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L): an update of a systematic review. Public Health Nutr 2000 Dec;3(4A);509-14.

19. Cutlan AR, Bonilla LE, Simon JE, Erwin JE. Intra-specific variability of feverfew: correlations between parthenolide, morphological traits and seen origin. Planta Med 2000 Oct;66(7):612-7.

20. Mauskop A, Fox B. What Your Doctor May Not Tell You About Migr. New York: Warner Books; 2001:79.

21. Mauskop A, Fox B. What Your Doctor May Not Tell You About Migrai. New York: Warner Books; 2001:52.

22. Brown DJ. Standardized butterbur extract Petadolexherbal approach to prophylaxis. Townsend Letter for Doctors and Patients, Oct 2002.

23. Russell AL, McCarty MF. Glucosamine for prophylaxis? Med Hypotheses 2000 Sep;55(3):195-8.

24. Rozen TD, Oshinsky ML, Gebeline CA, et al. Open label trial of coenzyme Q10 as a preventive. Cephalagia 2002 Mar;22(2):137-41.

25. Claustrat B, Brun J, Geoffriau M, Zaidan R, Mallo C, Chazot G. Nocturnal plasma melatonin profile and melatonin kinetics during infusion in status migrainosus support. Cephalagia 1997 Jun;17(4):511-7.

26. G.E. Abraham and J.D. Flechas, J of Nutr Medicine 1992; 3: 49-59.

Page 1 | Page 2 | Page 3 | Magnesium Malate - Fibromyalgia Support

Order: Magnesium | Migra-Eeze/Butterbur/Feverfew | Riboflavin/Vitamin B2

Give You and Your Loved Ones the Gift of Health! Special Sale! In addition to your 25% off, you get another 10% automatic volume discount at checkout on orders of $25 or more ... all items apply (including special sale items). SECURE SHOPPING CART CREDIT CARD PURCHASES ONLY. Call-ins do not receive this special discount.

Or Google Fast Checkout, PayPal, or send a check, money order, or cashiers check with completed order form.

Enjoy the benefits of our flat rate shipping and handling! You receive the same great service for the same shipping price whether you order one item or one hundred!

$5.97 - Within USA only - US Post Office 5-9 business days.

$16.97 - Within USA only - US Post Office 2-3 business days.

$37.87 - Within USA only - US Post Office Overnight (2nd day to rural areas).

$29.77 - To Canada only (see warning information here) 5-9 business days to customs check point (the only way we ship - US Post Office).

$39.77 - Outside USA only (see warning here) 7-10 business days to your country's customs check point (the only way we ship - US Post Office).

Save 8.25% on all purchases - Texans and everyone!

It's all tax free! You will be able to review all charges before they are charged to you.

At checkout (after you click the Add button above), the billing address you enter must match the address where you receive your credit card (security effects). The shipping address you enter does not have to match.

All orders placed by Noon Central Standard Time (CST) are shipped the same day. PO Boxes Okay.

Payment by credit card is immediate. Payment by check adds a few more business days -- as soon as funds clear.

We do not sell the information you give us to anyone.

Protecting Your Personal Information:
We pledge a safe and worry-free shopping experience using the industry standard for Internet security, 128-bit Secure Sockets Layer (SSL) encryption (see an online payments diagram). SSL scrambles your personal and credit card information as it travels the Internet during the checkout process. We utilize the Authorize.Net payment gateway. Your credit card information is encrypted and sent to an Authorize.Net transaction server. This server sends the data through the network to the card's bank, using a secure, proprietary connection. When complete, you will receive an approval or decline response. At no point is your credit card information stored on our server.

For additional information regarding the privacy of your sensitive cardholder data, please read the Authorize.Net Privacy Policy.