Indole-3-Carbinol (I3C) with Resveratrol extract, benefits

Dual-Action Cruciferous Vegetable Extract With Indole-3-Carbinol (I3C),
Resveratrol, & Cat's Claw -- Benefits, Dose

60 Vegetarian Capsules

Scientists have identified specific extracts from cruciferous vegetables (broccoli, cauliflower, Brussels sprouts, etc.) that modulate hormones in a way to help maintain healthy cell division. For instance, animal studies have shown that the cruciferous vegetable extract indole-3-carbinol (I3C) modulates estrogen hormones by favorably changing the ratio of protective 2-hydroxyestrone versus the damaging 16-hydroxyestrone.1 Indole-3-carbinol (I3C) also induces phase I and II detoxifying enzymes that can help neutralize estrogen metabolites and xenobiotic estrogen-like environmental chemicals.2 Human studies support the beneficial role of I3C in positively altering estrogen metabolism.3 Di-indolyl-methane (DIM), a phytonutrient found in cruciferous vegetables, has been shown in animal studies to help maintain normal levels of a potentially damaging estrogen called 4-hydroxyestrone.4

The glucosinolates are major constituents of cruciferous vegetables that have been shown to promote normal apoptosis and induce the expression of the beneficial p53 gene via an estrogen-independent action.5

Watercress contains isothiocyanates, but in a broader spectrum than does broccoli. The primary isothiocyanate precursor (PEiTC) in watercress functions via four specific mechanisms to maintain healthy cell division.6 Extracts from rosemary enhance liver metabolism of estradiol and estrone,7 inhibits the formation of DNA adducts,8 and have been shown to impede estrogen-induced growth promotion in certain tissues.7

Cat’s Claw, the Amazonian wonder herb, also known as Uncaria tomentosa or Uña de Gato, has been available for years, but there are various qualities of extracts. Dual-Action Cruciferous Vegetable products contain only Cat’s Claw water extract which has naturally occurring potent compounds called carboxy alkyl esters. These compounds, not found in typical Cat’s Claw products, have properties of DNA repair and anti-inflammation, and immune stimulation. Cat's claw protects cells against oxidative stress and inhibits lipopolysaccharide-induced iNOS gene expression, nitrite formation, cell death and inhibited the activation of NF-kappaB.9

The Cat’s Claw water extract material is produced through a patented aqueous extraction process which also removes tetracyclic oxindole alkaloids (TOA). TOA inhibit the activity of the other active compounds in Cat’s Claw, so it was highest priority to find a TOA-free Cat’s Claw to deliver maximum benefit.

The patented extraction process produces a standardized water soluble extract that can be readily absorbed by the body.

Life Extension has combined its cruciferous vegetable complex with a standardized resveratrol extract based on indications from published scientific literature that resveratrol may also be an effective plant extract for maintaining optimal health.

This organic whole-grape extract contains a spectrum of polyphenols naturally found in red wine, such as proanthocyanidins, anthocyanins, and flavonoids.

Supplement Facts
Serving Size 1 capsule -- Servings Per Container 60 -- Amount Per Serving
Broccoli (Brassica oleracea l.) Super Concentrate Extract (plant and sprouts) [std. to 4% glucosinolates (16 mg)]	400 mg
Watercress (Nasturtium officinale) 4:1 Extract (leaf)	100 mg
Indole-3-Carbinol (I3C)	80 mg
Rosemary (Rosmarinus officinalis) Extract (leaves) [std. to 20% diterpenic compounds (10 mg) and providing carnosic acid/carnosol]	50 mg
Cat's Claw (Uncaria tomentosa) Extract (bark) [std. to 8% carboxy alkyl esters (4 mg)]	50 mg
Resveratrol [from Red Grape (Vitis vinifera) Extract (whole fruit) and Polygonum cuspidatum Extract (root)]	20 mg
DIM (Di-indolyl-methane)	14 mg

Other ingredients: Rice flour, vegetable capsule, magnesium stearate, silica. Contains corn and rice. This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, or gluten. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

Caution: May interfere with oral contraceptives. If pregnant or intending to become pregnant, do not use this product. Do not use if taking antacids, H2-receptor blockers (e.g. Zantac®), or protonpump inhibitors (e.g. Nexium®), as these drugs may impede the conversion of I3C to active metabolites.

Dosage and Use:

The suggested dose is one capsule daily for individuals weighing up to 160 pounds.

For those weighing over 160 pounds, one capsule twice a day is suggested.

This product can be taken with or without food.

Warnings Information: This product is not intended to treat, cure, prevent or diagnose any disease.

Keep Indole-3-Carbinol (I3C) with Resveratrol extract out of reach of children

Do not exceed recommended dose

If you have a bad reaction, discontinue use immediately

When using Indole-3-Carbinol (I3C) with Resveratrol extract, please inform your physician.

References
1. Biochem Pharm. 2002, 64;393-404.
2. Toxicol Appl Pharm. 2001 Jul 15;174(2):146-52.
3. J Natl Cancer Inst. 1997 May 21;89(10):718-23.
4. Cancer Detect Prevent. 2004;28:72-9.
5. Carcinogenesis. 2002 Apr;23(4):581-6.
6. Mol Cancer Ther. 2003 Oct;2(10);1045-52.
7. Carcinogenesis. 1998 Oct;19(10):1821-7.
8. Carcinogenesis. 1995 Sep;16(9):2057-62.
9. Aliment Pharmacol Ther. 1998 Dec;12(12):1279-89.

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Indole-3-Carbinol (I3C) with Resveratrol, Extract, Benefits - Dose