GABA (gamma amino butyric acid) Supplement - Effects, Dose

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GABA (gamma amino butyric acid) Supplement - Effects, Dose GABA (gamma amino butyric acid) Powder 100 grams of pure powder

GABA (gamma-amino butyric acid) is an inhibitory neurotransmitter, helping neurons stay selective about the signals to which they respond and helping produce a state of relaxation.  Taken at bedtime, supplemental GABA may assist some people in the initiation of sleep and produce a deeper and more beneficial sleep. Gamma-aminobutyric acid (GABA), the brain’s major inhibitory neurotransmitter, tends to be in lower than normal levels in seizure-prone rats (1) and humans with epilepsy.(2)  Seizure-prone preeclamptic patients (hypertensive condition during late pregnancy) also have decreased brain GABA concentrations.(3)  Brain GABA levels depend on both zinc and vitamin B6.  Zinc is involved in the maintenance of pyridoxal phosphate concentrations by the activation of pyridoxal kinase.  Pyridoxal kinase is important in decarboxylation, and lack of this enzyme results in lowered brain levels of GABA.  Consequently, zinc deficiency may increase the risk of preeclamptic seizures by reducing brain GABA concentrations and lowering the seizure threshold.  Unfortunately, plasma pyridoxal phosphate measurements alone do not appear to accurately reflect vitamin B6 status or true tissue pyridoxal phosphate levels.(3) In addition to vitamin B6, magnesium and dimethylglycine have also frequently resulted in a rapid, sometimes overnight, appearance of speech in formerly non-speaking autistic children.  Magnesium, vitamin B6 and dimethylglycine all have strong anti-seizure properties and can be effective even when other anti-seizure medications fail.(5)  The deficiency of another member of the B-complex, B1, has also been reported as a contributor to epileptic seizures.(6) British researchers have found that the age-related decline in higher brain functions is due, in large part, to a lack of the inhibitory neurotransmitter, GABA.  Higher brain functions, such as visual recognition and language comprehension, decline as people get older.  This decline appears to be due to a reduction of GABA, which results in neurons with specific tasks being more easily fired by some other types of stimulus, slowing down processing of information in the brain. As people age, brain neurons increasingly fire non-selectively, and interpreting information then becomes like listening to “whispering in the discotheque as opposed to shouting in a quiet room.”  The new research shows that GABA works as a “gating” mechanism to help neurons remain selective when responding to stimuli to enable the brain to make sense of the vast quantity of incoming information. When old Macaque monkeys, equivalent to 90-year-old humans, were treated with GABA and drugs that increase GABA levels in the brain, their performance on tests for brain functions improved vastly within a couple of minutes.  “The fact is, all the cells are still there and functioning -- it’s a transmitter problem -- it’s treatable.”  While doctors have observed the paradoxical effect of GABA-enhancing drugs making people more alert, this is the first study to show that increasing GABA or its effects can support mental function.

Supplement Facts:  100 Gm Pure Powder.  Serving Size - 1/4 teaspoon.  Amount Per Serving GABA (gamma amino butyric acid) 700 mg

This product contains NO sugar, yeast, wheat, gluten, corn, soy or dairy. Contains NO artificial color, sweeteners, flavors or preservatives. Dosage and Use 1/8 - 1/4 teaspoon before sleep.GABA is most effectively utilized when taken on an empty stomach. It is easily soluble in juice or water and has a pleasant taste. GABA (gamma-amino butyric acid) may also be dissolved in the mouth for quicker assimilation.

Caution:  It is not advisable to take more than 750 mg per dose Warnings: Keep GABA (gamma amino butyric acid) amino acid supplements out of reach of children Do not exceed recommended dose If you have a reaction, discontinue use immediately When using GABA (gamma amino butyric acid) amino acid supplements, please inform your physician. Order:  GABA (gamma amino butyric acid) | L-Theanine | L-Glutamine | OptiZinc | Magnesium | Vitamin B6 1. Lasley, S. M. Role of Neurotransmitter Amino Acids in Seizure Severity and Experience in the Genetically Epilepsy-Prone Rat. Brain Res, 1991; 560:63-70 2. During, M.J. and Spencer, D. D. Extracellular Hippocampal Glutamate and Spontaneous Seizure in the Conscious Human Brain. The Lancet, June 26, 1993; 341 (8861): 1607-1610 3. Anonymous. Zinc, Preeclampsia, and Gamma-Aminobutyric Acid. Am Jnl of Obst & Gyn, July 1990, 163, 1, (Part I): 242-243 4. Baumeister, F. Glutamate in Pyridoxine-Dependent Epilepsy: Neurotoxic Glutamate Concentration in the Cerebrospinal Fluid and Its Normalization by Pyridoxine. Ped, September 1994, 94 (3): 318-321 5. Seizures, Vitamin B6, DMG, and Sudden Speech Autism, Res Rev Intl, 1996, 10 (2): 1 6. Keyser, A. Epileptic Manifestations and Vitamin B1 Deficiency. Eur Neuro, 1991, 31: 121-125

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