Forskolin - Leukemia, High Blood Pressure, Urinary Tract Infections Support

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Forskolin & its Effects on Leukemia, High Blood Pressure, & Urinary Tract Infections - Page 2
Reprinted by permission from Bill Faloon of The Life Extension Foundation

As seen on the Dr. Oz Show

In the November 2005 issue of the journal canc Cell, scientists from Ohio State University identified a new pathway of chronic myelogenous leukemia (CML) progression.  Chronic myelogenous leukemia develops when two chromosomes erroneously exchange genetic material during cell division, creating a new gene that produces the canc-causing enzyme Bcr-Abl.  Bcr-Abl turns cell growth signals on, which, when unchecked by phosphatases, result in the abnormal production of white blood cells.  The disease is currently treated with the so-called wonder-drug Gleevec which blocks Bcr-Abl activity.  Unfortunately, a large number of patients develop resistance to the treatment.

Until now, it was unknown how the disease progressed through its well defined stages.  Dr. Danilo Perrotti and colleagues discovered that Bcr-Abl stimulates the protein SET which inhibits the tumor suppressor phosphatase PP2A.  He is an assistant professor in the department of molecular virology, immunology and medical genetics at Ohio State University.  The team discovered that in chronic myelogenous leukemia, PP2A suppression only occurs in the final, acute stage of the disease.

Forskolin, extracted from the root of the ornamental plant coleus forskohlii, can restore PP2A function based on previous research findings.  The extract was tested on normal, Gleevec-sensitive and Gleevec-resistant human CML cells.  The researchers found that forskolin restored normal PP2A function while reducing the canc cells' ability to grow by up to 90 percent.  It also induced canc cell death and differentiation while failing to effect normal cells.  When forskolin was tested on mice, withdrawal of the compound resulted in the death of some of the animals while others showed signs of Bcr-Abl activity.  But, when forskolin was re-administered, Bcr-Abl was blocked.

Dr. Perotti commented, "We believe these are significant findings.  We have uncovered a key process that underlies progression in CML and identified an agent that can block it.  We also have shown that forskolin can reinstate normal cell functioning even in Gleevec-resistant cells that do not respond to any treatment currently available."

Cardiac Energy and High Blood Pressure
Between 1981 and 1994, an herbal extract called forskolin was tested in over 5,000 in vitro studies to assess its cell regulating effects.

Forskolin appears to be effective in high blood pressure support, improving arterial blood flow, strengthening heart muscle contraction, and relieving angina (heart) pain.

In a human study involving seven patients with dilated cardiomyopathy, forskolin was shown to improve left ventricular function, (Arzneim Forsh 37:364-7).  This confirmed earlier animal studies showing that forskolin increases the contractile force of the heart muscle.

In the Journal of Cardiovascular Pharmacology (16/1 1990), forskolin's multiple cardiovascular actions were investigated in cardiomyopathy patients.  Forskolin was shown to reduce systolic and diastolic blood pressure and pulmonary artery pressure with a concomitant increase in cardiac output.  Cardiac stroke volume and stroke volume index was increased by 70%.  The authors of the study concluded that forskolin may be used for the treatment of severe heart failure and high blood pressure.

How Forskolin Works
Studies show that forskolin works by producing a potent arterial muscle relaxing effect.  High blood pressure is often caused by a reduction in arterial elasticity.  The vasodilating effects of forskolin are thought to be the mechanism responsible for its blood pressure lowering effects.

Forskolin's energy-enhancing effects are due to its unique ability to stimulate adenylate cyclase activity and elevate cyclic adenosine monophosphate (cAMP) levels.  cAMP regulates and activates critical enzymes required for cellular energy.

Forskolin can be used safely by healthy people and can be taken by those with heart disease or high blood pressure to improve cardiovascular health.

Physician Cooperation Essential
Please inform your physician if you are taking anti-hypertensive drugs and are interested in taking forskolin for high blood pressure.  Extreme caution is mandatory and physician cooperation is essential for those with heart disease and high blood pressure.

Forskolin and Urinary Tract Infections (UTI)
In a letter published online on April 8, 2007 in the journal Nature Medicine, Soman Abraham and his associates at Duke University Medical Center described their finding that an over the counter extract of the Indian coleus plant known as forskolin can significantly reduce urinary tract infections and could enhance the ability of antibiotics to destroy E. coli, the bacteria that causes most bladder infections. The herb is currently an ingredient in some body-building products, and is used to enhance lean body mass.

"This herb has been used in Asia for centuries for a wide variety of ailments," Dr. Abraham said. "However, one of its constant uses has been for treating painful urination."

In several experiments using mice, the Duke team found that some bacteria retreat to cells lining the bladder where antibiotics cannot reach them.  "After customary antibiotic treatment, the vast majority of the bacteria are either killed by the antibiotics or eliminated during urination," Dr. Abraham explained.  "However, there are small numbers of bacteria that survive antibiotic treatment because they sneak into the lining of the bladder, waiting for the opportunity, after antibiotic treatment, to come out and start multiplying again."

Although the lining of the bladder is resistant to penetration, pouchlike structures that enable the organ to stretch create niches in which E. Coli can reside.  By enhancing specific cellular activity, forskolin causes these pouches to flush their E. Coli colonies into the urine, rendering the bacteria destructible by antibiotics.

Because the current research used injectable and intravenous forskolin, Dr. Abraham is planning to test the compounds efficacy when administered orally.  "This type of treatment strategy may prove to be beneficial for patients with recurrent urinary tract infections," Dr. Abraham predicted.  "Ideally, use of this herb would expel the bacteria, where it would then be hit with antibiotics.  With the reservoir of hiding bacteria cleared out, the urinary tract infection should not recur."

Warnings Information:

  • For dietary supplement use only,
  • Keep Forskolin (coleus forskohlii) supplements for Leukemia, High Blood Pressure, and Urinary Tract Infections support out of reach of children,
  • Do not exceed recommended dosage,
  • If you have a bad reaction or side effects, discontinue use immediately,
  • When using Forskolin (coleus forskohlii) supplements, please inform your physician,
  • If you are pregnant, lactating or have a medical condition, consult your health care professional before using this or any other nutritional supplement for Leukemia, High Blood Pressure or Urinary Tract Infections support.

Forskolin (Coleus Forskohlii) Weight Loss, Side-Effects, Obesity, Dose - Page 1

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