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Female Non-Smokers Suffer Disproportionately
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Researchers have only recently begun investigating why women who have never smoked are more likely to develop lung cancer than their male counterparts. Studies of mice suggest that estrogen may play a role, Schiller says. About 95% of lung cancers in both sexes have estrogen receptors, Siegfried says. She and Schiller are involved in research looking at whether Faslodex, an anti-estrogen drug used to treat metastatic breast cancers that contain estrogen receptors, might be effective against metastatic lung cancers in women. Genetics also might play a role in lung cancer risk. Just months before Reeve was diagnosed, her mother died of ovarian cancer. Siegfried says her research has found a disproportionate number of breast and ovarian cancers among the relatives of women with lung cancer. Lung cancer itself appears to run in the Scarangello family. Joan Scarangello McNeive never smoked, but she died in 2001 at age 47, just nine months after she was diagnosed with lung cancer. McNeive died 20 years after her mother, who also never smoked, died at age 50, also just nine months after being diagnosed with lung cancer. When McNeive was diagnosed, her family realized that "nothing had changed in 20 years," says her brother's wife, Roxanne Donovan, a founding board member of Joan's Legacy, a New York-based non-profit group that has awarded $1.3 million for lung cancer research. "There was nothing they could do for Joan," Donovan says. "There was nothing they could do for her mother." To see more of USAToday.com, or to subscribe, go to http://www.usatoday.com |
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