D, L-Phenylalanine (DLPA)
by Dusty R. Green, M.Ed., Research Scientist & Author of
Smart Supplements, and Smart Exercise
D, L-Phenylalanine (DLPA) is a 50-50 blend of the D and L forms of this amino acid
(building blocks for protein). The structure of the D form is used
to help combat pain (salicylic acid, a component of
aspirin, is biosynthesized from phenylalanine).
structure of the L form is used as a stimulant,
enhancer. D, L-Phenylalanine is used by the brain to produce
norepinephrine (our brains' version of adrenaline), a neurotransmitter depleted by stress, caffeine, nicotine, pollution, and
some pharmacological and recreational drugs. D, L-Phenylalanine also helps replace
dopamine, the neurotransmitter responsible for feelings associated with
confidence, and euphoria virtually side effect free.
D, L-Phenylalanine is the precursor to another amino acid
called tyrosine. Tyrosine also does all of the above except for one
factor -- chocolate (beta phenylethylamine), a
neuromodulator associated with mood enhancement and sexual stimulation. Tyrosine does not
appear to be as active in this role as chocolate and DLPA. This may be the reason
some people refer to chocolate as sexual stimulant. Unfortunately, all
those extra calories from consuming the amount of chocolate needed for sexual
stimulation would pile-on body fat in short-order. If you are a chocoholic
(for sexual stimulation or not) and want to
lower your intake, phenylalanine or Fastin may be the answer for you.
DL-Phenylalanine and Starbucks
D, L-Phenylalanine (or tyrosine) works especially well with
caffeine. Caffeine gives us a temporary lift by sending norepinephrine (neurotransmitter
associated with mental sharpness, excitability, pain, and
into the blood stream. Over time, healthy levels of norepinephrine are depleted by
caffeine and other factors mentioned above ... if not replaced. Phenylalanine
does a great job replacing this major neurotransmitter.
Studies show that cocaine
users who are trying to quit may benefit from
use. The chronic use of cocaine
may eventually cause the side effects of depletion of
dopamine and norepinephrine from the brain without replacing these two
valuable neurotransmitters. As dopamine is synthesized from
precursors such as DL-Phenylalanine (DLPA)
and theanine, dopamine
reserves are rebuilt, thus, overcoming the problem of dopamine depletion. The use of DLPA on a regular basis may be a
so-called "antidote" for those who are trying to quit
cocaine. One of cocaine's principal effects is the blocking of the
re-uptake of dopamine in the brain. This results in increased dopamine levels associated with the euphoric characteristic of the drug. However, chronic use of cocaine
may lead to considerable dopamine reduction.
In addition, cocaine users often exhibit
various nutritional deficiencies (a myriad of side effects on their own). Consequently, it is strongly
to provide certain vitamins and minerals to ones supplement protocol,
particularly vitamin C, pantothenic acid (vitamin
and zinc. All of the above supplements are included in a multi-vitamin product called
Life Extension Mix. Vitamins B6 and C are important
co-factors in the synthesis and structure of dopamine,
Editors note (7-14-08):
Customers/clients have been reporting a kinship of consuming 2 products simultaneously to that of feelings associated with an enhanced "natural high." D, L-phenylalanine
(DLPA) is one and the other is
After a few anecdotal reports, I decided to use myself as a "guinea pig" while extrapolating the research. I now have to concur that there is a nice 'high" (so-to-speak) that lasts for 4-6 hours/dose. In addition, consider the positive benefits of dropping body fat.
Continued here ...
Have you ever wondered why cigarette smokers enjoy "lighting-up" after sex?
There is evidence to support the notion that smoking appears to release dopamine into the brain.
As a result, smokers appear to get a mild hit of dopamine by "lighting-up"
after an orgasm.
This may be
one of the main reasons "kicking the smoking habit" is so difficult. Cigarette smokers may find it quite easy to become ex-smokers with the use of phenylalanine.
Many ex-smokers gain weight right after quitting and use weight gain
as a reason to keep smoking. Phenylalanine encourages the hypothalamus in the brain
to release CCK
(cholecystokinin), the hormone responsible for signaling fullness.
phenylalanine may eliminate ex-smokers weight gain excuse virtually side
D, L-Phenylalanine should not be confused with
phenylpropanolamine (a form of amphetamine). Phenylpropanolamine is an appetite
depressant used in several over-the-counter diet pills. It causes the brain to use up its
stores of nor-epinephrine without stimulating it to produce more.
Typically, after about two weeks, the dieter stops taking the diet pill which
can result in "the blues" and low energy since they are
running low on norepinephrine. They then gorge themselves on food and end up gaining more
weight than before.
Phenylalanine and tyrosine should be used with
caution by those with hypertension,
phenylketonuria (PKU) (a rare genetic defect of the
brain), or pre-existing pigmented melanoma (a type of skin cancer). Nor, should they be
used in combination with anti-depressant drugs.
I was reluctant to use phenylalanine for
several years because of the above cancer warning. Skin cancer
developed on my face (two separate
areas) in my younger years and I was afraid it would get worse. One of the areas displayed a constant
oozing sore and the other was a sore red area about a half-inch in diameter.
decided to take phenylalanine in the name of science. A couple of months after I had
been using it daily, the cancer disappeared even while spending a lot of time in the sun.
I am not making the claim that phenylalanine cured the cancer. I am saying that my skin
cancer is now gone. That happened around the time I added phenylalanine,
and 750 mg.
of butylated hydroxytoluene (BHT) to my daily routine.
BHT is a common
food preservative and powerful
(free radical scavenger). There is a lot of evidence that the consumption of
canthaxanthin and 500-1000 mg
of BHT per day is beneficial to those who have
cancer. In addition, BHT supports the health of those with both type I and type II herpes and some forms of HIV
virtually side effects free.
grape seed extract was added about that
time to Life Extension Mix (which I take).
Grape seed extract is one of the most powerful
anti-oxidants known to man. It also works along with
billberry extract to improve microcapillary
circulation throughout the body. My point in bringing this up is: Even though there
is a universal warning about the use of phenylalanine and tyrosine pertaining to skin
cancer, they did not make my condition worse. In fact, approximately 18 years later, I have no signs of skin cancer anywhere on my body even
though I spend a lot of time in the sun.
D, L-Phenylalanine competes with other amino
acids. They have to be able to pass through the stomach and blood brain barrier without
competition. The consensus of experts recommend taking phenylalanine on an empty stomach
before eating. Avoid taking them with other amino acids (there are a few in
Extension Mix multi-formula) or other supplement formulas. It is recommended
to start with 500-1,000
mg as soon as you awake. Some people take another
500-1,000 mg 4-6 hours later for that extra "lift." As a
possible side effect, taking it too
close to bedtime may keep you awake. Some people build up (after taking
lower doses for a couple of weeks) to 2,000 mg in
the morning and 2,000 mg in the evening.
There has to be significant amounts of
vitamin B6 and
present in your blood stream in order for phenylalanine (or tyrosine) to work. The
ingestion of 150-200 mg of Vitamin B6 and 3,000-4,000 mg of vitamin C divided throughout the
day does a great job ... in addition to other benefits as mentioned in the
above links. There are 100 mg of
vitamin B6 and 2,500 mg of vitamin C in the full menu
of Life Extension Mix.
Cancer patients should avoid taking L-phenylalanine and L-tyrosine. Certain cancers, such as melanoma, depend on these amino acids to fuel their growth. Supplemental use of L-phenylalanine and L-tyrosine may raise or normalize blood pressure. Insomnia may
be a side effect if
taken too close to bedtime.
- Keep out of reach of children,
- Do not exceed recommended dose,
- If you have a bad reaction
or side effects,
discontinue use immediately,
- When using DL Phenylalanine (dlpa),
please inform your physician.
- Pg 1 |
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