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Novel Form of CoQ10 -- Ubiquinol
When it comes to achieving optimal
results from coenzyme Q10 (CoQ10), how much you absorb is of critical
importance. Recently published studies conclusively show that higher
CoQ10 blood levels provide far greater benefits.
Two years ago, Life Extension introduced
a patented CoQ10 absorption technology that delivered significantly
greater amounts of this essential nutrient into the bloodstream. Over
the past nine months, Life Extension researchers have spent enormous
resources improving coenzyme Q10 absorption rates.
In what is an
economic setback for Life Extension, but a huge
breakthrough for consumers, the largest Japanese
producer of CoQ10 has patented a novel form of
coenzyme Q10.
It
increases human blood levels up to 8-times more efficient than
expensive, higher-absorption CoQ10 products offered by commercial
companies.
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Based on the indisputable supremacy of
this novel form of Japanese CoQ10, the resources expended by Life
Extension this year to improve its own CoQ10 absorption technology have
gone to waste.
Why Life Extension Is Thrilled to Lose
Its Investment
If Life Extension functioned only as a
profit-making commercial company, the news of a superior competitive
product would have been a major economic disappointment.
Instead, Life Extension Researchers were
elated when they found that this new form of CoQ10 was 40% more
effective than conventional CoQ10 in slowing aging markers in
middle-aged mice.
It's impressive enough to review the
statistics on this new form of CoQ10, such as a study on aged rats that
documents the 2.5 times greater anti-fatigue effects compared to
conventional CoQ10 supplements.1
What has Life Extension researchers astounded, however, is seeing the
actual video footage of the mice themselves in response to this superior
form of CoQ10.
The video shows that the aging group of
mice receiving no supplementation is essentially immobile and
unresponsive, exhibiting lesions in and around the eye with spinal and
limb deformities and a patchy, discolored coat. Many of these
pathological events that are seen in the mice not supplemented with
CoQ10 are classic signs of degenerative aging suffered by humans. Aging
mice supplemented with this novel form of CoQ10, on the other hand, are
alert, responsive and energetic with no physical lesions or deformities,
and a glossy coat resembling that of a young, healthy mouse.2
As one can clearly see by the three still
photos, the mouse receiving no CoQ10 suffered severe aging
consequences, whereas the mouse receiving conventional CoQ10 suffered
noticeable, but not as harsh degenerative changes. The mouse receiving
the new form of CoQ10, on the other hand, appears to be very healthy.
As
a whole, the group who received the new form CoQ10 aged 40% slower than
the group receiving conventional CoQ10 and 51% slower than the group
receiving no CoQ10.2
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These pictures were taken of
senescent-accelerated mice at around 12 months of age. The
control mouse at the top received no coenzyme Q10 and
underwent the severe degenerative changes that normally occur
in this breed of mouse.
The mouse in the middle
received conventional coenzyme Q10 and displayed a slower rate
of aging compared to the group receiving no coenzyme Q10.
The mouse at the bottom
received the new ubiquinol form of coenzyme Q10 and was
shown to age 40% slower than the group receiving conventional
coenzyme Q10. Compared to the controls who received no
coenzyme Q10, the group who received the new ubiquinol
coenzyme Q10 aged at a 51% slower rate.
Yellow Arrows:
Bended backbone
Blue Arrows: Irritation
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Why This New Form of CoQ10
Works So Much Better
Coenzyme Q10 exists in both
ubiquinol and ubiquinone forms, but they have very different
roles to play in the body. For the first time, a stabilized
ubiquinol form of CoQ10 is available in capsule form. When
compared to conventional (ubiquinone) CoQ10 supplements, the
benefits of ubiquinol are enormously superior.
For example, a recent
peer-reviewed study measured the absorption in humans
supplementing with 150 mg and 300 mg of this new ubiquinol
form of coenzyme Q10.3
As can be seen in the chart below, far lower doses of
ubiquinol produce about the same blood (plasma) levels
compared with much higher doses of ubiquinone. This chart
shows that it takes 8-times more ubiquinone to increase CoQ10
blood levels to what can be achieved with much lower doses of
ubiquinol. |
What may also make this novel form of
CoQ10 so much more effective than CoQ10 supplements on the market today
is its ability to remain biologically active in the body much longer.
In
a study on aged rats, blood concentrations of this new ubiquinol CoQ10
was 3.75-fold greater after eight hours compared to the same amount of
conventional coenzyme Q10.2
The superior absorption and ability to
remain bioavailable over a greater sustained time period may account for
the unprecedented anti-senescent effects observed with new ubiquinol
compared to ubiquinone.
In what may be the most profound
anti-senescent discovery ever made about a dietary supplement,
scientists have demonstrated that this novel form of coenzyme Q10 is
vastly superior to the CoQ10 supplements that millions of Americans use
today.
Since this novel CoQ10 absorbs so much
better, and remains in the bloodstream so much longer than conventional
supplements, fewer milligrams are needed to provide greater effects.
Each capsule of the new Super Bio-Active CoQ10 provides 50 mg of this
novel ubiquinol form of coenzyme Q10.
Compared to other commercial
supplements, taking just three 50 mg ubiquinol capsules a day provides
the human body with the equivalent of over 1000 mg of
enhanced-absorption conventional coenzyme Q10. For most healthy people,
one capsule of the new Super BioActive CoQ10 taken two times a day will
provide significantly higher blood levels than the CoQ10 they are
presently taking.
More people are supplementing with CoQ10
than ever before. One reason is increased awareness that "statin"
drugs used to lower LDL and cholesterol deplete CoQ10 levels in the
blood, and possibly the tissues.
What most doctors dont know, however, is
that normal aging may result in more of a reduction in CoQ10 than
taking statins. For example, while statin drugs have been shown to
reduce plasma CoQ10 by 40%, the aging
process reduces CoQ10 levels in the heart muscle wall by 72%.
What is particularly frightening is the deficit caused by the dual
effects of aging and statin drug use
that can result in severe depletion of cellular vitality.
When CoQ10 is orally ingested, only a
certain percentage is actually absorbed into the bloodstream.
Findings in human subjects indicate that higher doses of CoQ10
provide significantly better effects than the doses supplement users
typically take. Since CoQ10 is a comparatively expensive nutrient,
an alternative to taking higher doses is to increase the amount of
CoQ10 that is absorbed. Life Extension offers the highly
bioavailable ubiquinol form of CoQ10 in a patented delivery system
with a superior absorption level.
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CoQ10 is notoriously difficult to absorb.
When it comes to choosing a CoQ10 supplement, the primary factor is
how many swallowed milligrams actually make it into your
bloodstream. A recent study showed that in seriously ill patients,
conventional ubiquinone CoQ10 was hardly detectable in the blood
whereas ubiquinol resulted in significant blood level increases and
subsequent clinical improvements.
Scientific studies show that ubiquinol
absorbs up to 8 times greater than ubiquinone, and higher levels of
ubiquinol remain in the blood far longer than ubiquinone. In studies
measuring exercise-induced fatigue, ubiquinol was 90% more effective
than ubiquinone. In middle-aged mice, ubiquinol was shown to be 40%
more effective in slowing measurements of aging compared to
ubiquinone.
This latest formulation contains an organic
compound called PrimaVie
shilajit that research shows
doubles
levels of
CoQ10
in the
mitochondria.
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Shilajit
has been shown to help restore and sustain
cellular energy. The latest studies reveal that when
shilajit
is combined with CoQ10, cellular energy gains substantially
increase.
In a breakthrough preliminary study, the
combination of CoQ10 and shilajit produced a
56% increase
in cellular energy production in the brain
40% better
than CoQ10 alone. In muscle there was a
144% increase,
or 27% better
than CoQ10 alone.
Researchers have found that shilajit works to
boost CoQ10s beneficial effects by:
- Stabilizing CoQ10 in its superior
ubiquinol form, thereby prolonging its action at the cellular
level.
- Facilitating more efficient delivery of CoQ10 into the
mitochondria, resulting in greater cellular energy output.
Scientific analysis shows that shilajit itself is rich in
essential compounds that promote mitochondrial metabolism. Part
of shilajits beneficial effects derives from its ability to
help the mitochondria convert fats and sugars into
adenosine triphosphate, or
ATP --
the bodys main source of energy.
Super Ubiquinol CoQ10 with Enhanced
Mitochondrial Support combines
super absorbable ubiquinol CoQ10 with shilajit to generate a
powerful synergy that supports more youthful cellular energy
production than CoQ10 alone.
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