Coenzyme-Q10 from Ubiquinol -- Side-Effects, Benefits

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Coenzyme-Q10 (Co-Enzyme-Q-10) Ubiquinol -- Side-Effects, Benefits
Up to Eight-Times More Bioavailable -- Newest Formulas

Novel Form of CoQ10 -- Ubiquinol

When it comes to achieving optimal results from coenzyme Q10 (CoQ10), how much you absorb is of critical importance.  Recently published studies conclusively show that higher CoQ10 blood levels provide far greater benefits.

Two years ago, Life Extension introduced a patented CoQ10 absorption technology that delivered significantly greater amounts of this essential nutrient into the bloodstream.  Over the past nine months, Life Extension researchers have spent enormous resources improving coenzyme Q10 absorption rates.

In what is an economic setback for Life Extension, but a huge breakthrough for consumers, the largest Japanese producer of CoQ10 has patented a novel form of coenzyme Q10.

It increases human blood levels up to 8-times more efficient than expensive, higher-absorption CoQ10 products offered by commercial companies.

Based on the indisputable supremacy of this novel form of Japanese CoQ10, the resources expended by Life Extension this year to improve its own CoQ10 absorption technology have gone to waste.

Why Life Extension Is Thrilled to Lose Its Investment
If Life Extension functioned only as a profit-making commercial company, the news of a superior competitive product would have been a major economic disappointment.

Instead, Life Extension Researchers were elated when they found that this new form of CoQ10 was 40% more effective than conventional CoQ10 in slowing aging markers in middle-aged mice.

It's impressive enough to review the statistics on this new form of CoQ10, such as a study on aged rats that documents the 2.5 times greater anti-fatigue effects compared to conventional CoQ10 supplements.1   What has Life Extension researchers astounded, however, is seeing the actual video footage of the mice themselves in response to this superior form of CoQ10.

The video shows that the aging group of mice receiving no supplementation is essentially immobile and unresponsive, exhibiting lesions in and around the eye with spinal and limb deformities and a patchy, discolored coat.  Many of these pathological events that are seen in the mice not supplemented with CoQ10 are classic signs of degenerative aging suffered by humans.  Aging mice supplemented with this novel form of CoQ10, on the other hand, are alert, responsive and energetic with no physical lesions or deformities, and a glossy coat resembling that of a young, healthy mouse.2

As one can clearly see by the three still photos, the mouse receiving no CoQ10 suffered severe aging consequences, whereas the mouse receiving conventional CoQ10 suffered noticeable, but not as harsh degenerative changes.  The mouse receiving the new form of CoQ10, on the other hand, appears to be very healthy.  As a whole, the group who received the new form CoQ10 aged 40% slower than the group receiving conventional CoQ10 and 51% slower than the group receiving no CoQ10.2

These pictures were taken of senescent-accelerated mice at around 12 months of age.  The control mouse at the top received no coenzyme Q10 and underwent the severe degenerative changes that normally occur in this breed of mouse.

The mouse in the middle received conventional coenzyme Q10 and displayed a slower rate of aging compared to the group receiving no coenzyme Q10.

The mouse at the bottom received the new ubiquinol form of coenzyme Q10 and was shown to age 40% slower than the group receiving conventional coenzyme Q10.  Compared to the controls who received no coenzyme Q10, the group who received the new ubiquinol coenzyme Q10 aged at a 51% slower rate.

Yellow Arrows: Bended backbone
Blue Arrows: Irritation

Why This New Form of CoQ10 Works So Much Better

Coenzyme Q10 exists in both ubiquinol and ubiquinone forms, but they have very different roles to play in the body. For the first time, a stabilized ubiquinol form of CoQ10 is available in capsule form.  When compared to conventional (ubiquinone) CoQ10 supplements, the benefits of ubiquinol are enormously superior.

For example, a recent peer-reviewed study measured the absorption in humans supplementing with 150 mg and 300 mg of this new ubiquinol form of coenzyme Q10.3  As can be seen in the chart below, far lower doses of ubiquinol produce about the same blood (plasma) levels compared with much higher doses of ubiquinone.  This chart shows that it takes 8-times more ubiquinone to increase CoQ10 blood levels to what can be achieved with much lower doses of ubiquinol.

What also makes this novel form of CoQ10 so much more effective than CoQ10 supplements on the market today is its ability to remain biologically active in the body much longer.  In a study on aged rats, blood concentrations of this new ubiquinol CoQ10 was 3.75-fold greater after eight hours compared to the same amount of conventional coenzyme Q10.2

The superior absorption and ability to remain bioavailable over a greater sustained time period may account for the unprecedented anti-senescent effects observed with new ubiquinol compared to ubiquinone.

In what may be the most profound anti-senescent discovery ever made about a dietary supplement, scientists have demonstrated that this novel form of coenzyme Q10 is vastly superior to the CoQ10 supplements that millions of Americans use today.

Since this novel CoQ10 absorbs so much better, and remains in the bloodstream so much longer than conventional supplements, fewer milligrams are needed to provide greater effects.  Each capsule of the new Super Bio-Active CoQ10 provides 50 mg of this novel ubiquinol form of coenzyme Q10.

Compared to other commercial supplements, taking just three 50 mg ubiquinol capsules a day provides the human body with the equivalent of over 1000 mg of enhanced-absorption conventional coenzyme Q10.  For most healthy people, one capsule of the new Super BioActive CoQ10 taken two times a day will provide significantly higher blood levels than the CoQ10 they are presently taking.

More people are supplementing with CoQ10 than ever before. One reason is increased awareness that "statin" drugs used to lower LDL and cholesterol deplete CoQ10 levels in the blood, and possibly the tissues.

What most doctors don't know, however, is that normal aging may result in more of a reduction in CoQ10 than taking statins.  For example, while statin drugs have been shown to reduce plasma CoQ10 by 40%, the aging process reduces CoQ10 levels in the heart muscle wall by 72%.  What is particularly frightening is the deficit caused by the dual effects of aging and statin drug use that can result in severe depletion of cellular vitality.

When CoQ10 is orally ingested, only a certain percentage is actually absorbed into the bloodstream.  Findings in human subjects indicate that higher doses of CoQ10 provide significantly better effects than the doses supplement users typically take.  Since CoQ10 is a comparatively expensive nutrient, an alternative to taking higher doses is to increase the amount of CoQ10 that is absorbed.  Life Extension offers the highly bioavailable ubiquinol form of CoQ10 in a patented delivery system with a superior absorption level.

CoQ10 is notoriously difficult to absorb.  When it comes to choosing a CoQ10 supplement, the primary factor is how many swallowed milligrams actually make it into your bloodstream.  A recent study showed that in seriously ill patients, conventional ubiquinone CoQ10 was hardly detectable in the blood whereas ubiquinol resulted in significant blood level increases and subsequent clinical improvements.

Scientific studies show that ubiquinol absorbs up to 8 times greater than ubiquinone, and higher levels of ubiquinol remain in the blood far longer than ubiquinone.  In studies measuring exercise-induced fatigue, ubiquinol was 90% more effective than ubiquinone.  In middle-aged mice, ubiquinol was shown to be 40% more effective in slowing measurements of aging compared to ubiquinone.

This latest formulation contains an organic compound called PrimaVie shilajit that research shows doubles levels of CoQ10 in the mitochondria.

Shilajit has been shown to help restore and sustain cellular energy.  The latest studies reveal that when shilajit is combined with CoQ10, cellular energy gains substantially increase.

In a breakthrough preliminary study, the combination of CoQ10 and shilajit produced a 56% increase in cellular energy production in the brain 40% better than CoQ10 alone.  In muscle there was a 144% increase, or 27% better than CoQ10 alone.

Researchers have found that shilajit works to boost CoQ10s beneficial effects by:

  1. Stabilizing CoQ10 in its superior ubiquinol form, thereby prolonging its action at the cellular level.
  2. Facilitating more efficient delivery of CoQ10 into the mitochondria, resulting in greater cellular energy output.  Scientific analysis shows that shilajit itself is rich in essential compounds that promote mitochondrial metabolism.  Part of shilajit's beneficial effects derives from its ability to help the mitochondria convert fats and sugars into adenosine triphosphate, or ATP -- the body's main source of energy.

Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support combines super absorbable ubiquinol CoQ10 with shilajit to generate a powerful synergy that supports more youthful cellular energy production than CoQ10 alone.

50 mg Supplement Facts:  Serving Size - 1 softgel.  Servings Per Container - 100

Amount/Serving

Calories

2

Calories from Fat

2

Total Fat

0.2 g

Ubiquinol (*Kaneka QH reduced) form of CoQ10

50 mg

PrimaVie Shilajit fulvic acid complex

50 mg
 

100 mg Supplement Facts:  Serving Size - 1 softgel.  Servings Per Container - 60

Amount/Serving

Calories

4

Calories from Fat

3

Total Fat

0.37 g

Ubiquinol (*Kaneka QH reduced) form of CoQ10

100 mg

*PrimaVie Shilajit fulvic acid complex 100 mg
 

200 mg Supplement Facts:  Serving Size - 1 softgel.  Servings Per Container - 30

Calories 10
Calories from Fat 10
Total Fat .74 g
Ubiquinol (*Kaneka QH reduced) form of CoQ10 200 mg
*PrimaVie Shilajit fulvic acid complex 200 mg

Other ingredients:  Safflower oil, gelatin, glycerin, beeswax, lecithin, water, polyglycerol fatty acid ester, caramel color.  Contains soybeans.  This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), tree nuts, wheat, yeast, gluten, corn, or rice.  Contains NO sugar, and no artificial sweeteners, flavors, or preservatives.

*Kaneka QH is a trademark of Kaneka Corporation.
*PrimaVie is a registered trademark of Natreon, Inc.

Dosage and Use:  Take one softgel with food and a glass of water twice daily, or as recommended by a healthcare practitioner.

Warnings Information:

  • Keep out of reach of children,

  • For the most benefits, do not exceed recommended dosage,

  • If you have a bad reaction or side effects, discontinue use immediately,

  • When using Coenzyme Co Q10 supplements, please inform your physician.

References:
1. Kaneka Corporation study. Treadmill test with the aged rat at age of 61-63 weeks. 2006.
2. Yan J, Fujii K, et al. Exp Gerontol. 2006 Feb;41(2):130-40.
3. Hosoe K, Kitano M, et al. Regul Toxicol Pharmacol. 2006, Aug 17

More References

More Information | Pg 2 | Pg 3 | CoQ10 & Ischemic Heart Disease

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