Boswellia (boswella) Serrata Extract (boswellic-acid) Effects, Complex

Boswellia (boswella) Serrata Extract -- 70% Total Organic Boswellic Acid) - Dose

Boswellia is an herb that has anti-inflammatory support in acute and chronic models. It does not produce an analgesic effect, but may aid in the suppression of inflammation, the underlying cause of pain. Studies also show, as a result, it may reduce joint swelling and morning stiffness while supporting mobility without the side effects that are characteristic of prescription drugs.

Leukotrienes are considered to be involved in the initiation and continuation of a variety of inflammatory conditions. Leukotrienes cause inflammation by promoting free radical damage, calcium dislocation, auto-immune responses, cell adhesion, and the migration of inflammatory producing cells to the inflamed body area. Boswella possibly blocks the synthesis of leukotrienes which is how it may be inhibiting inflammation.

By Vitamin Research Staff
Boswellia Serrata may improve intestinal health in patients with colitis, according to the results of a new study.

Researchers set out to study the side effects of boswellia serrata extract on symptoms, quality of life, and structure of colonic tissue in patients with a type of inflammatory bowel disorder known as collagenous colitis. The researchers chose to test boswellia because it has demonstrated anti-inflammatory effects in past studies.

Twenty-six patients with chronic diarrhea and collagenous colitis were randomized to receive either 400 mg of oral boswellia serrata extract or a placebo three times per day for 6 weeks. Complete colonoscopy and histology (the study of the microscopic structure of tissue) were performed before and after giving subjects the botanical or the placebo. Clinical symptoms and quality of life were assessed by standardized questionnaires. The scientists then determined the percentage of patients with clinical remission after 6 weeks. In addition, after that time, patients in the side effects free placebo group with persistent diarrhea received boswellia serrata for a further 6 weeks.

Results indicated that although boswellia serrata had no effect on histology and quality of life, the proportion of patients in clinical remission was higher in the boswellia serrata group than in the placebo group. Furthermore, of the seven patients who started out in the placebo group but who were given boswellia after the initial phase of the trial had concluded, five achieved complete remission.

The researchers concluded, "Our study suggests that boswellia serrata extract might be clinically effective in patients with collagenous colitis. Larger trials are clearly necessary to establish the clinical efficacy of boswellia serrata extract."

Reference for above:
Madisch A, Miehlke S, Eichele O, Mrwa J, Bethke B, Kuhlisch E, Bstlein E, Wilhelms G, Morgner A, Wigginghaus B, Stolte M. Boswellia serrata extract for the treatment of collagenous colitis. A double-blind, randomized, placebo-controlled, multicenter trial. Int J Colorectal Dis. 2007 Dec;22(12):1445-51.

Mechanism of Actions of Curcumine and Boswellic Acids

J. ETHNOPHARMACOL. (Ireland), 1993, 38/2-3 (113-119)

Circumin from curcuma longa and the gum resin of boswellia serrata were demonstrated to support the actions of being anti-inflammatories in in-vivo animal models. They were studied in a set of in-vitro experiments in order to elucidate the mechanism of their beneficial positive side effects. Circumin inhibited the 5-lipoxygenase activity in rat peritoneal neutrophils as well as the 12-lipoxygenase and the cyclooxygenase activities in human platelets. In a cell-free peroxidation system, circumin exerted strong antioxidative activity. Thus, its effects on the dioxygenases are probably due to its reducing capacity. Boswellic acids were isolated from the gum resin of Boswellia serrata and identified as the active principles. Boswellic acids inhibited the leukotriene synthesis via 5-lipoxygenase but did not affect the 12-lipoxygenase and the cyclooxygenase activities. Additionally, boswellic acids did not impair the peroxidation of arachidonic acid by iron and ascorbate. The data suggest that boswellic acids are specific, non-redox inhibitors of leukotriene synthesis either interacting directly with 5-lipoxygenase or blocking its translocation.

Effects of Boswellia Serrata Gum Resin

Gupta I; Parihar A; Malhotra P; Singh GB; Ludtke R; Safayhi H; Ammon HP Department of Medicine, Govt. Medical College, Jammu, J&K, India. Eur J Med Res (GERMANY) Jan 1997, 2 (1) p37-43,

The colon, where leukotrienes are suggested to play an important role for keeping inflammation active, is an area receptive to the benefits of boswella. Boswellic acids, the biologically active ingredients of the gum resin of boswellia serrata (sallai guggal), have been shown to be specific, non-redox and non-competitive inhibitors of 5-lipoxygenase, the key enzyme of leukotriene biosynthesis. In patients suffering from painful colon conditions, grade II and III, the effect of Boswellia serrata gum resin preparation (350 mg thrice daily for 6 weeks) on stool properties, histolopathology and scan microscopy of rectal biopsies, blood parameters including Hb, serum iron, calcium, phosphorus, proteins, total leukocytes and eosinophils was studied. Patients receiving sulfasalazine (1g thrice daily) served as controls. All parameters tested, improved after treatment with Boswellia serrata gum resin -- the results being similar compared to controls -- 82% out of treated patients went into remission; in case of sulfasalazine remission rate was 75%.

Recommended dosage: The recommended dose is one 250 mg capsule three times per day for a month. As an adjunct, some cycle or use it with the enzyme bromelain, circumin and/or a product called NutriJoint which contains glucosamine, chondroitin, collagen, silica, and MSM all of which are virtually side effects free.

Warnings Information:

Keep out of reach of children,
Do not exceed recommended dosage,
If you have a bad reaction or side effects to boswellic acids, discontinue use immediately,
When using boswellia (boswella) serrata extract supplement, please inform your physician.

More Information: Glucosamine, Chondroitin Sulfate, MSM, Sulphate | pH Acid/Alkaline Article

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Supplement Facts: Serving Size - 1 Vegetarian Capsule. 90 capsules, 250 mg each
	Amount/Serving	% Daily Value
Boswellia (Boswellia serrata) extract (gum) -- 70% total organic boswellic acids.	250 mg	*
Other Ingredients: Hydroxypropylmethylcellulose (vegetarian capsule). Contains no added sugar, starch, salt, wheat, gluten, corn, coloring, dairy products, flavoring or preservatives.
*Daily Value not established

Boswellia (boswella) Serrata Extract - Side Effects, Benefits, Herbs - Dose