Adipocytes, Adipose, Lipolysis, Belly Fat Buring Obesity Cells, AdipoStat

Health authorities are warning about the devastating consequences of obesity, yet doctors remain in the dark about what causes people to accumulate so many fat pounds as they age.

Through a series of well-designed studies, scientists investigating certain plant extracts found they can block fat storage at the cellular level.

In a significant scientific advance, a potent new weapon has been identified to help safely induce weight loss.

This article describes how a novel dual plant extract favorably modulates six pathways that fat cells use to trigger weight gain.

When tested on humans in a placebo-controlled study, those taking this dual plant extract lost 4.05 inches of abdominal fat and dropped 11.4 pounds after eight weeks with weight loss observed as early as 14 days.1

Cells that store fat are called adipocytes. They are deposited throughout our bodies.2,3

Dual Plant Extract Burning Fat Cells

As we age, adipocytes tend to expand and congregate in areas that are cosmetically unsightly and detrimental to our health.

Of greatest concern are the adipocytes that deposit deep in our abdomens. This visceral fat represents more than fat stored on our waistlines. Visceral fat is chemically active tissue that churns out a torrent of pro-inflammatory cytokines.4

Those with bulging belly fat suffer constant bombardment from toxic cytokines that trigger the metabolic syndrome and its deadly consequences.5,6

This widespread problem led scientists to seek out plant extracts that specifically interfere with adipocyte fat storage in our abdominal anatomy.

Sphaeranthus Indicus

How Unwanted Fat Storage Occurs
Excess calories transform to fat deposits in adipocytes7 through a multi-step process known as adipogenesis.

When fewer calories are consumed, fat is released from adipocytes to meet the bodys energy needs.8,9 This is known as lipolysis.

A dual plant extract has been studied based on its ability to simultaneously inhibit adipogenesis (fat storage) and enhance lipolysis (fat breakdown and release).

Mangosteen Fruit

Like any other cell, adipocytes develop from undifferentiated stem cells. Premature, developing fat cells are called pre-adipocytes. When you ingest more calories than your body needs, young pre-adipocytes respond by maturing into adult adipocytes.7,10-12

Adult adipocytes take up excess fatty acids from your bloodstream and begin expanding. It is this process of fatty acid uptake and adipocyte expansion that ultimately results in obesity and its pathologic consequences. Every excess calorie contributes to the maturation and growth of fat cells in this way. Past a certain point, adipocytes distend and become bloated, much in the same way your belly does.

Not all adipocytes are the same. While fat cells distribute throughout your body, those that store in your abdomen -- producing so-called visceral fat or belly fat -- are more than just storage containers.

Belly fat cells are chemically active. They form fatty tissue capable of releasing detrimental pro-inflammatory cytokines.4

In obese individuals, the mass of excess visceral fat deposits generates a pro-inflammatory flood of cytokines. This cytokine release then incites a cascade of harmful effects that, if left unchecked, contributes to the onset of multiple degenerative diseases.5,6

So unwanted body fat storage happens when pre-adipocyte stem cells mature in order to store excess dietary fat (adipogenesis) while the ability to break down stored fat (lipolysis) diminishes.

What You Need to Know: Inhibiting Cellular Fat Storage

An obesity epidemic continues to rage in this country, with more than two-thirds of the American population overweight or obese,
Conventional medicine has yet to offer any safe, long-term, practical solution,
Cutting-edge researchers continue to identify novel natural weight loss -- inducing agents,
Among the most recent is a dual plant extract containing extracts of the flower S. indicus and the mangosteen fruit, both native to Asia,
When combined, the resulting dual extract blend was found to favorably influence six distinct biomolecular pathways by which fat cells trigger weight gain. In placebo-controlled clinical trials involving obese subjects, this dual extract safely induced total weight loss of 11.4 pounds, a decline of 2.05 in body mass index (BMI), and a reduction of 4.05 inches in harmful visceral fat after just eight weeks.1

Combating Surplus Body Fat Storage
Searching for natural interventions that would effectively inhibit fat accumulation (adipogenesis) and enhance fat burning (lipolysis), scientists evaluated more than a thousand plants for evidence that would meet this criteria.13

Two plants whose extracts demonstrated significant biological effects were:

Sphaeranthus indicus flower (S. indicus)13
Mangosteen fruit (Garcinia mangostana).13

Control adipocyte cells not treated with S. indicus display lipid accumulation.

Adipocyte cells treated with S. indicus inhibited fat accumulation.

In the laboratory, S. indicus and mangosteen extracts powerfully impeded adipogenesis.

When cells were treated with S. indicus alone, fat storage was inhibited by as much as 65%, compared with control cells. Photographs (below) show a markedly visible difference between the two cell groups. The control cells show a bloated, foamy appearance, bulging with fat droplets, compared to the smaller, more naturally contoured cells treated with the S. indicus extract.13

Each of these extracts also enhanced lipolysis (or fat burning), by as much as 56% compared to control cells.13

Having identified these unifying properties in the two extracts, the researchers set out to determine if they would exhibit enhanced effects when used in combination.

They found that the S. indicus and mangosteen extracts favorably modulate the activity of six genomic pathways involved in fat cell formation and breakdown.13

Remarkably, these extracts reduced gene expression that promotes adipogenesis while favorably influencing a gene involved in desirable lipolysis.

The box on this page shows how these plant extracts, used alone and in combination, positively modulated the markers involved in unwanted cellular fat accumulation by inhibiting adipogenesis and promoting lipolysis.

Given these observations, researchers recognized that this novel blend of plant extracts could result in significant weight loss via three distinct mechanisms:

Preventing young fat cells (pre-adipocytes) from developing into mature fat cells (adipocytes),
Reducing the amount of fatty acids adipocytes could absorb,
Speeding breakdown of bloated adipocytes existing fat stores.

The next step was to determine if these plant extracts would induce weight loss in experimental animals and -- more importantly -- obese humans.

Preventing Obesity in Rodents
When young adult rats are fed a high-fat diet they rapidly gain weight -- just as humans often do.

To investigate the effects of the plant extracts that worked in cell studies, scientists fed a group of young adult rats a high-fat diet. Half the rats received the dual plant extract while the other half served as the control group.13

At the end of eight weeks, the control group rapidly gained weight. The rats fed a high-fat diet and given the dual plant extract, on the other hand, reduced body weight gain by an impressive 700%.13

This is not surprising considering these same plant extracts blocked fat accumulation by 48.5% and 65.9% in the cellular model.13

This study demonstrated that these plant extracts decrease diet-induced obesity in young adult rats. The real challenge, however, is whether these same plant extracts are effective in humans who are already obese.

Anti-Adipocyte Formula with AdipoStat - Ingredients/Dose | Page 2 | References

Give You and Your Loved Ones the Gift of Health! Special Sale! In addition to your 25% off, you get another 10% automatic volume discount at checkout on orders of $25 or more ... all items apply (including special sale items). SECURE SHOPPING CART CREDIT CARD PURCHASES ONLY. Call-ins do not receive this special discount.

Or Google Fast Checkout, PayPal, or send a check, money order, or cashiers check with completed order form.

Enjoy the benefits of our flat rate shipping and handling! You receive the same great service for the same shipping price whether you order one item or one hundred!

$5.97 - Within USA only - US Post Office 5-9 business days.

$16.97 - Within USA only - US Post Office 2-3 business days.

$37.87 - Within USA only - US Post Office Overnight (2nd day to rural areas).

$29.77 - To Canada only (see warning information here) 5-9 business days to customs check point (the only way we ship - US Post Office).

$39.77 - Outside USA only (see warning here) 7-10 business days to your country's customs check point (the only way we ship - US Post Office).

Save 8.25% on all purchases - Texans and everyone!

It's all tax free! You will be able to review all charges before they are charged to you.

At checkout (after you click the Add button above), the billing address you enter must match the address where you receive your credit card (security effects). The shipping address you enter does not have to match.

All orders placed by Noon Central Standard Time (CST) are shipped the same day. PO Boxes Okay.

Payment by credit card is immediate. Payment by check adds a few more business days -- as soon as funds clear.

We do not sell the information you give us to anyone.

Protecting Your Personal Information:
We pledge a safe and worry-free shopping experience using the industry standard for Internet security, 128-bit Secure Sockets Layer (SSL) encryption (see an online payments diagram). SSL scrambles your personal and credit card information as it travels the Internet during the checkout process. We utilize the Authorize.Net payment gateway. Your credit card information is encrypted and sent to an Authorize.Net transaction server. This server sends the data through the network to the card's bank, using a secure, proprietary connection. When complete, you will receive an approval or decline response. At no point is your credit card information stored on our server.

For additional information regarding the privacy of your sensitive cardholder data, please read the Authorize.Net Privacy Policy.

Adipocytes, Adipose Obesity, Belly Fat Buring Cells, AdipoStat - Page 1